Symposium – Monday July 21 
Neutron Scattering in Cryobiological Research
Chair: Eugene Mamontov – Oak Ridge National Laboratory

Achieving predictive understanding of the function of biosystems, ranging from biomolecules to organisms, is a great scientific challenge. Because biological function of a system is defined by both its structure and dynamics, experimental probes with the spatial and temporal range commensurate with the intra- and inter- biomolecular space dimensions and the rate of molecular motions could be particularly valuable in biological research. While no single experimental method covers the entire range of the relevant space and time scales, neutron scattering techniques are sensitive to the processes on a length scale from Angstroms to hundreds of nanometers and a time scale from sub-picoseconds to hundreds of nanoseconds. Other important advantages of neutron scattering include a large difference in signal between protons and deuterons, which could be used to emphasize the signal from the selected components of the biosystem, and non-destructive character of neutrons as a probe, which allows application of neutron scattering to living systems, where x-ray or electron beam would be prohibitively damaging. Historically, these advantages of neutron scattering were broadly utilized in biological research at low temperatures, as attested to, e.g., by the prominent role played by neutrons in studies of protein dynamical transition. However, in the recent years, the range of biosystems amenable to neutron scattering studies at temperatures from ambient to cryogenic greatly expanded beyond hydrated biomolecules, to include cellular cultures, tissues, organs, and, possibly, multicellular organisms. This symposium will highlight recent advances and outline future directions in the application of neutron scattering in cryobiological research.

Lorna Dougan – University of Leeds
Low-density water structure captured in nanosegregated cryoprotectant solution

Victoria Garcia-Sakai – Rutherford Appleton Laboratory
Can neutrons help understand cryopreservation protocols?

Eugene Mamontov – Oak Ridge National Laboratory
Hydration patterns in multicellular organisms from neutron scattering measurements of the freezing

Symposia – Tuesday July 22
Preservation of Cellular Therapies:  Practical Realities and Emerging Approaches
Chair: Allison Hubel – University of Minnesota 

Session Description Coming Soon

Allison Hubel – University of Minnesota 
Please check back soon for additional speakers 

Biopreservation Considerations for Cell Therapy GMP Manufacturing Development & Commercialization
Chair: Aby Mathew – BioLife Solutions, Inc., ISCT

Session Description Coming Soon

Wen Bo Wang – Fate Therapeutics
Aby J. Mathew – BioLife Solutions, Inc.; ISCT

Cryopreservation of Aquatic organisms
Chair: Estefania Paredes – University of Vigo, Spain

Applying a wide variety of technologies/tools from traditional cryopreservation to novel techniques like vitrification with laser warming, the aim of this session is to discuss advances in cryobiology carried out with aquatic organisms for conservation, research and Aquaculture.

Estefania Paredes – University of Vigo, Spain
Cryoprervation of Neoplasic cells from the mollusc Cerastoderma edule

Johnathan Daly – University of Hawaii/Smithsonian Institute
Laser Warming in Coral Larvae

Leandro Godoy – Federal University Rio Grande do Sul, Brazil
ReefBank Project – Coral Reef Conservation in Brazil

Peter Wilson – SCRIPPS/USA
Cold Water Diatoms

Jessica Bouwmeester – University of Hawaii/Smithsonian Institute
Long-term Effects of Coral Bleaching on the Cryophysiology of Coral Symbiotic Dinoflagellates

Symposia Wednesday July 23
Nature’s Way: New Insights on Hibernation and Survival in the Cold

Chair: Kenneth Storey – Carleton University

The solution to winter survival for many species is hibernation. Recent advances in technologies, new ideas about regulatory mechanisms, and broader studies of diverse species are rapidly expanding our knowledge about animal life in the cold and generating new ideas applicable to medical science.

Fabrice Bertile – Centre National de la Recherche Scientifique (CNRS), France
Warm Hibernation in Bears

Ryan Sprenger – University of British Columbia, Canada
Cold Hibernation in Mammals

Roberta Gottlieb – UCLA, USA
Cold Adaptations in Pigs and Mice

CJ Niu – Beijing Normal University, China
Cold Adaptation in Reptiles

Ken Storey – Carleton University, Canada
Marsupials and Primates  – New Animal Models 

Yunfang Gao – Northwest University, Xi’an, China
Muscle Plasticity in Hibernation

Symposia – July 24
Commercial and Best Practice Aspects of Biobanking – in association with ISBER
Chairs: Aby Mathew – BioLife Solutions, Inc.; ISCT and David Lewandowski – President, ISBER; Brooks Life Science Systems

Session Description Coming Soon

Dayong Gao – President, Society for Cryobiology; University of Washington
David Lewandowski – President, ISBER; Brooks Life Science Systems 
John M. Baust – CPSI Biotech 

High Subzero Temperature Preservation of Organs and Tissues
Chair: Jedediah Lewis – CEO, Organ Preservation Alliance

Session Description Coming Soon

Korkut Uygun – Massachusetts General Hospital
Michael Taylor – Sylvatica Biotech
Mehmet Toner – Massachusetts General Hospital



Schedule Outline. May be subject to change. 

Sunday July 21
9:00 AM- 5:00 PM: Board of Governors Meeting
12:00 PM – 8:00 PM: Registration
7:00 PM – 9:00 PM: Welcome Reception

Monday July 22
8:30 AM – 8:00 PM: Scientific Program

Tuesday July 23
8:30 AM – 8:00 PM: Scientific Program 
Tuesday features an all day cellular therapy track in addition to standard programming. 

Wednesday July 24
8:30 AM – 6:00 PM: Scientific Program 
8:00 Am – 6:00 PM: Plant Cryo excursion to Huntington Botanical Garden

Thursday July 25
8:30 AM – 4:00 PM: Scientific Program
4:00 PM – 5:00 PM: Society for Cryobiology AGM
6:00 PM –>: Awards and Banquet